Start by spraying the air fryer basket with nonstick spray and preheat your air fryer to 370°F (190°C).

In a large bowl, combine the ground beef, egg, panko bread crumbs, yellow mustard, ketchup, Worcestershire sauce, minced onion, salt, pepper, onion powder, and garlic powder. Using clean hands or gloves, mix everything together until well combined. Tip: Don’t overmix; this keeps the patties tender.

Shape the mixture into 12 equal patties and place them in the greased air fryer basket. Depending on your air fryer size, you may need to cook them in two batches.

Cook the patties for 6 minutes at 370°F (190°C). After 6 minutes, carefully flip the patties and cook for an additional 3 minutes. Tip: Use a spatula to avoid breaking the patties while flipping.

Once the cooking time is up, remove the basket from the fryer and brush barbecue sauce on all sides of the patties. Return the basket to the air fryer and cook for another 2 minutes, ensuring the internal temperature of the beef reaches 160°F (71°C).

Allow the patties to rest for 3 minutes before serving. They pair wonderfully with mashed potatoes or white rice. Tip: For a heartier meal, consider serving with a side of steamed vegetables.